Composition
Each ml contains:
Phenylbutazone: 200mg
Dexamethasone (as sodium phosphate): 0.38 mg
Excipient: Q.S.P. 100 ml
Mechanism of Action
Dexamethasone: A member of the glucocorticoid family, it exerts pharmacologic effects on all body cells. It provides powerful immunosuppressive and anti-inflammatory actions by inhibiting lytic enzymes released during inflammation and severe stress, while also decreasing macrophage phagocytosis.
Phenylbutazone: An NSAID that inhibits prostaglandin inflammatory effects which cause pain and fever. It interferes in the early stages of inflammation, reducing vascular bed permeability to prevent edema and diapedesis. The combination provides predominant anti-inflammatory and pain relief results.
Indications of Use
Used as an anti-inflammatory, antipyretic, and analgesic agent. Specifically indicated for musculoskeletal inflammations such as arthritis, osteoarthritis, laminitis, and tendonitis in horses.
Dosage and Administration
| Target Animal |
Dosage and Route |
| Horses |
20 ml/day by slow IV injection; can be repeated depending on severity. |
| Foals |
6 - 10 ml by slow IV or deep IM; to be repeated 24 - 48 hours later depending on severity. |
Contraindications & Precautions
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Contraindications: Do not use in animals with heart, liver, or kidney problems, or in the end term of pregnancy. Decrease dosage in cases of vascular brittleness.
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Precautions:
- Use within 28 days after first opening.
- Do not use concurrently with other NSAIDs or corticosteroids.
- IV injections must be administered slowly.
- Keep out of reach of children and strictly follow veterinary prescriptions.
Storage Conditions
Protect from direct sunlight. Store at temperatures between 15 - 25° C. Keep vials protected in their boxes.
Seaoriva Medical
